A low cost and highly flexible
intraoperative endomicroscopy system for cellular
imaging
Posted on 2018-02-21 - 15:53
Optical biopsy such as probe-based endomicroscopy represent a promising technique that can provide useful intraoperative assessment of
cellular imaging instead of conventional physical biopsy and histology. Despite these merits of endomicroscopy, however, it is limited by high cost of
the optical system, difficulties in flexible approach by a commercial probe, large area surveillance and tissue deformation. In this paper, we have
developed a low cost endomicroscopy system with highly flexible fiber bundle coupled with a distal micro-lens, mosaicing algorithm and robotic
scanning device for obtaining large area in vivo cellular imaging to extend the clinical application of endomicroscopy. We have demonstrated that this
system can obtain good quality images from ex vivo human stomach tissue. And we have also shown the potential of the system to provide a much
larger field of view for optical biopsy than conventional endomicroscopy. This could greatly improve the prospects for intraoperative in vivo and in
situ evaluation of cellular imaging.
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WANG, HAIBO; ZHANG, NACHUAN; Zuo, Siyang (2018). A low cost and highly flexible
intraoperative endomicroscopy system for cellular
imaging. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.3919918.v1
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