Femtosecond-laser stimulation induces senescence of tumor cells in vitro and in vivo

Posted on 14.01.2022 - 16:48
Tumor cells present anti-apoptosis and abnormal proliferation during development. Senescence and stemness of tumor cells play a key role in tumor development and malignancy. In this study, we show the transient stimulation by a single-time scanning of tightly focused femtosecond laser to tumor cells can modulate the stemness and senescence in vitro and in vivo. The laser-induced cellular senescence and stemness present distinct transitions in vitro and in vivo. The cells more than 1 mm deep in tumor tissue are found be with significant senescence induced by the transient photostimulations at 100-200 µm shallow layer which suppresses the growth of whole tumor in living mice.

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Zhao, Xiaohui; Tang, Wanyi; Wang, Haipeng; He, Hao (2022): Femtosecond-laser stimulation induces senescence of tumor cells in vitro and in vivo. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.5757434.v2
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AUTHORS (4)

Xiaohui Zhao
Wanyi Tang
Haipeng Wang
Hao He

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