Low-cost, chromatic confocal endomicroscope for cellular imaging in vivo
Posted on 2021-08-16 - 14:43
We have developed a low-cost, chromatic confocal endomicroscope (CCE) that can image a cross-section of the tissue at cellular resolution. In CCE, a custom miniature objective lens was used to focus different wavelengths into different tissue depths. Therefore, each tissue depth was encoded with the wavelength. A custom miniature spectrometer was used to spectrally-analyze light reflected from the tissue and generate cross-sectional confocal images. The CCE prototype had a diameter of 9.5 mm and a length of 68 mm. Material cost of the CCE prototype was less than $1,500. Measured resolution was high, 2 µm and 4 µm for lateral and axial directions, respectively. Preliminary results showed that CCE can visualize cellular details from cross-sections of the tissue in vivo down to the tissue depth of 100 µm.
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Kulkarni, Nachiket; Masciola, Andrew; Nishant, Abhinav; Kim, Kyung-Jo; Choi, Heejoo; Gmitro, Arthur; et al. (2021): Low-cost, chromatic confocal endomicroscope for cellular imaging in vivo. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.5533095.v1
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